Anti-ADCK3 antibody (AA39644)


Alternative names Atypical kinase ADCK3, mitochondrial, EC 2.7.-.-, Chaperone activity of bc1 complex-like, Chaperone-ABC1-like, aarF domain-containing protein kinase 3, ADCK3, CABC1, PP265, ADCK3_HUMAN, Q8NI60, 56997
Source 647
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Product name Anti-ADCK3 antibody (AA39644)
Catalog number AA39644
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Atypical kinase ADCK3, mitochondrial antibody, EC 2.7.-.- antibody, Chaperone activity of bc1 complex-like antibody, Chaperone-ABC1-like antibody, aarF domain-containing protein kinase 3 antibody, ADCK3 antibody, CABC1 antibody, PP265 antibody, ADCK3_HUMAN antibody

Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target Name ADCK3
SwissProt ID Link Q8NI60
Function Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144). Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway (PubMed:25498144). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).
Subcellular Location Mitochondrion. Membrane; Single-pass membrane protein.
Involvement in Disease Coenzyme Q10 deficiency, primary, 4: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.
Subunit Structure Homodimer; homodimerizes via its transmembrane region.
Sequence Similarities Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3

Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.