Anti-ADAMTS4 antibody (AA26720)

$187.00


Alternative names A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, EC 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688, UNQ769/PRO1563, ATS4_HUMAN, O75173, 9507
Source 837
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ADAMTS4 antibody (AA26720)
Catalog number AA26720
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody, ADAM-TS 4 antibody, ADAM-TS4 antibody, ADAMTS-4 antibody, EC 3.4.24.82 antibody, ADMP-1 antibody, Aggrecanase-1 antibody, ADAMTS4 antibody, KIAA0688 antibody, UNQ769/PRO1563 antibody, ATS4_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ADAMTS4
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ADAMTS4
SwissProt ID Link O75173
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Post-Translational Modification The precursor is cleaved by a furin endopeptidase.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Tissue Specificity Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium.
Subunit Structure Interacts with SRPX2.
Sequence Similarities Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 1 TSP type-1 domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.