Anti-ADAM12 antibody (AA41299)

$187.00


Alternative names Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, EC 3.4.24.-, Meltrin-alpha, ADAM12, MLTN, UNQ346/PRO545, ADA12_HUMAN, O43184, 8038
Source 909?738?
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ADAM12 antibody (AA41299)
Catalog number AA41299
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Disintegrin and metalloproteinase domain-containing protein 12 antibody, ADAM 12 antibody, EC 3.4.24.- antibody, Meltrin-alpha antibody, ADAM12 antibody, MLTN antibody, UNQ346/PRO545 antibody, ADA12_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name ADAM12
SwissProt ID Link O43184
Function Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.; Isoform 4: Secreted.
Post-Translational Modification The precursor is cleaved by a furin endopeptidase.
Tissue Specificity Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
Subunit Structure Interacts with alpha-actinin-2 and with syndecans. Interacts with SH3PXD2A. Interacts with FST3. Interacts with GNB2L1/RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.
Sequence Similarities Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.