Anti-ACSL6 antibody (AA41374)

$187.00


Alternative names Long-chain-fatty-acid--CoA ligase 6, EC 6.2.1.3, Long-chain acyl-CoA synthetase 6, LACS 6, ACSL6, ACS2, FACL6, KIAA0837, LACS5, ACSL6_HUMAN, Q9UKU0, 23305
Source 697?622?
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ACSL6 antibody (AA41374)
Catalog number AA41374
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Long-chain-fatty-acid--CoA ligase 6 antibody, EC 6.2.1.3 antibody, Long-chain acyl-CoA synthetase 6 antibody, LACS 6 antibody, ACSL6 antibody, ACS2 antibody, FACL6 antibody, KIAA0837 antibody, LACS5 antibody, ACSL6_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name ACSL6
SwissProt ID Link Q9UKU0
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Subcellular Location Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Involvement in Disease A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia . Translocation t(5;12)(q31;p13) with ETV6.
Tissue Specificity Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
Sequence Similarities Belongs to the ATP-dependent AMP-binding enzyme family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.