Anti-ACHE antibody (AA24293)

$287.00


Alternative names Acetylcholinesterase, AChE, EC 3.1.1.7, ACES_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-ACHE antibody (AA24293)
Catalog number AA24293
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Acetylcholinesterase antibody, AChE antibody, EC 3.1.1.7 antibody, ACES_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ACHE
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ACHE
SwissProt ID Link P22303
Function Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Subcellular Location Cell junction, synapse. Secreted. Cell membrane; Peripheral membrane protein.; Isoform T: Nucleus. Only observed in apoptotic nuclei.; Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Tissue Specificity Isoform H is highly expressed in erythrocytes.
Subunit Structure Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers. Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.
Sequence Similarities Belongs to the type-B carboxylesterase/lipase family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.