Anti-ACAT1 antibody (AA34165)


Alternative names Acetyl-CoA acetyltransferase, mitochondrial, EC, Acetoacetyl-CoA thiolase, T2, ACAT1, ACAT, MAT, THIL_HUMAN, P24752, 38
Source 427
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Product name Anti-ACAT1 antibody (AA34165)
Catalog number AA34165
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Acetyl-CoA acetyltransferase, mitochondrial antibody, EC antibody, Acetoacetyl-CoA thiolase antibody, T2 antibody, ACAT1 antibody, ACAT antibody, MAT antibody, THIL_HUMAN antibody

Biological Information

Immunogen Recombinant protein of human ACAT1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target Name ACAT1
SwissProt ID Link P24752
Function Plays a major role in ketone body metabolism.
Subcellular Location Mitochondrion.
Involvement in Disease 3-ketothiolase deficiency: An inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype. The disease is caused by mutations affecting the gene represented in this entry.
Post-Translational Modification Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5.
Subunit Structure Homotetramer.
Sequence Similarities Belongs to the thiolase family.

Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3

Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.