Anti-ACACA antibody (AA22166)

$287.00


Alternative names Acetyl-CoA carboxylase 1, ACC1, EC 6.4.1.2, ACC-alpha, ACACA, ACAC, ACCA, ACACA_HUMAN
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-ACACA antibody (AA22166)
Catalog number AA22166
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Acetyl-CoA carboxylase 1 antibody, ACC1 antibody, EC 6.4.1.2 antibody, ACC-alpha antibody, ACACA antibody, ACAC antibody, ACCA antibody, ACACA_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ACACA
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ACACA
SwissProt ID Link Q13085
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Subcellular Location Cytoplasm.
Involvement in Disease Acetyl-CoA carboxylase 1 deficiency: An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth. The disease is caused by mutations affecting the gene represented in this entry.
Post-Translational Modification Phosphorylation on Ser-1263 is required for interaction with BRCA1.
Tissue Specificity Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Subunit Structure Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Sequence Similarities Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.