Anti-ABI2 antibody (AA31700)

$287.00


Alternative names Abl interactor 2, Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ABI2, ARGBPIA, ABI2_HUMAN, Q9NYB9, 10152
Source 513
Species Reactivity Human, Mouse, Rat
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ABI2 antibody (AA31700)
Catalog number AA31700
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Abl interactor 2 antibody, Abelson interactor 2 antibody, Abi-2 antibody, Abl-binding protein 3 antibody, AblBP3 antibody, Arg-binding protein 1 antibody, ArgBP1 antibody, ABI2 antibody, ARGBPIA antibody, ABI2_HUMAN antibody


Biological Information

Concentration 1 mg/ml
Isotype IgG
Purification method Purified by affinity chromatography


Target

Target Name ABI2
SwissProt ID Link Q9NYB9
Function May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Subcellular Location Cytoplasm.; Isoform 1: Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
Post-Translational Modification Is a substrate for ABL1.
Subunit Structure Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with ABL1 and ABL2. Interacts with human cytomegalovirus UL135.
Sequence Similarities Belongs to the ABI family. Contains 1 SH3 domain. Contains 1 t-SNARE coiled-coil homology domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 C. Avoid multiple freeze/thaw cycles.