Anti-ABHD5 antibody (AA38021)

$287.00


Alternative names 1-acylglycerol-3-phosphate O-acyltransferase ABHD5, EC 2.3.1.51, Abhydrolase domain-containing protein 5, Lipid droplet-binding protein CGI-58, ABHD5, NCIE2, CGI-58, ABHD5_HUMAN, Q8WTS1, 51099
Source 349
Species Reactivity Human, Mouse
Applications IF/ICC, IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ABHD5 antibody (AA38021)
Catalog number AA38021
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 antibody, EC 2.3.1.51 antibody, Abhydrolase domain-containing protein 5 antibody, Lipid droplet-binding protein CGI-58 antibody, ABHD5 antibody, NCIE2 antibody, CGI-58 antibody, ABHD5_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ABHD5
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Purification method Purified by affinity chromatography


Target

Target Name ABHD5
SwissProt ID Link Q8WTS1
Function Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.
Subcellular Location Cytoplasm. Lipid droplet. Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.
Involvement in Disease Chanarin-Dorfman syndrome: An autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Clinical characteristics are congenital generalized ichthyosis, vacuolated leukocytes, hepatomegaly, myopathy, cataracts, neurosensory hearing loss and developmental delay. The disorder presents at birth with generalized, fine, white scaling of the skin and a variable degree of erythema resembling non-bullous congenital ichthyosiform erythroderma. The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
Subunit Structure Interacts with ADRP, PLIN and PNPLA2. Interacts with PLIN5; promotes interaction with PNPLA2.
Sequence Similarities Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.