Anti-ABCG8 antibody (AA25262)

$187.00


Alternative names ATP-binding cassette sub-family G member 8, Sterolin-2, ABCG8, ABCG8_HUMAN, Q9H221, 64241
Source 673
Species Reactivity Human, Mouse, Rat
Applications IHC, WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ABCG8 antibody (AA25262)
Catalog number AA25262
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names ATP-binding cassette sub-family G member 8 antibody, Sterolin-2 antibody, ABCG8 antibody, ABCG8_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human ABCG8
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name ABCG8
SwissProt ID Link Q9H221
Function Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Subcellular Location Membrane; Multi-pass membrane protein.
Involvement in Disease Gallbladder disease 4: One of the major digestive diseases. Gallstones composed of cholesterol: Rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Strongly expressed in the liver, lower levels in the small intestine and colon. Detectable in a wide variety of human tissues.
Subunit Structure May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion.
Sequence Similarities Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Contains 1 ABC transmembrane type-2 domain. Contains 1 ABC transporter domain.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.