Anti-ABCA1 antibody (AA39225)

$187.00


Alternative names ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ABC-1, ATP-binding cassette 1, Cholesterol efflux regulatory protein, ABCA1, ABC1, CERP, ABCA1_HUMAN, O95477, 19
Source 2261
Species Reactivity Human, Mouse, Rat
Applications WB
Host Rabbit
Class Polyclonal
Conjugated Unconjugated


Description

Product name Anti-ABCA1 antibody (AA39225)
Catalog number AA39225
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names ATP-binding cassette sub-family A member 1 antibody, ATP-binding cassette transporter 1 antibody, ABC-1 antibody, ATP-binding cassette 1 antibody, Cholesterol efflux regulatory protein antibody, ABCA1 antibody, ABC1 antibody, CERP antibody, ABCA1_HUMAN antibody


Biological Information

Immunogen Synthetic peptide of human ABCA1
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000
Purification method Purified by affinity chromatography


Target

Target Name ABCA1
SwissProt ID Link O95477
Function cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
Subcellular Location Membrane; Multi-pass membrane protein.
Involvement in Disease High density lipoprotein deficiency 1: Recessive disorder characterized by absence of high density lipoprotein: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease and a reduction in cellular cholesterol efflux. The disease is caused by mutations affecting the gene represented in this entry.
Post-Translational Modification Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization.
Tissue Specificity Widely expressed, but most abundant in macrophages.
Subunit Structure Interacts with MEGF10.
Sequence Similarities Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.