Anti-AACT antibody (AA23378)

$187.00


Alternative names Alpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3, AACT, GIG24, GIG25, AACT_HUMAN
Species Reactivity Human
Applications IHC, WB
Host Rabbit
Conjugated Unconjugated


Description

Product name Anti-AACT antibody (AA23378)
Catalog number AA23378
Brand family Ango
Product type Primary Antibody
Antibody Alternative Names Alpha-1-antichymotrypsin antibody, ACT antibody, Cell growth-inhibiting gene 24/25 protein antibody, Serpin A3 antibody, SERPINA3 antibody, AACT antibody, GIG24 antibody, GIG25 antibody, AACT_HUMAN antibody


Biological Information

Immunogen Recombinant protein of human SERPINA3
Concentration 1 mg/ml
Isotype IgG
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Purification method Purified by affinity chromatography


Target

Target Name AACT
SwissProt ID Link P01011
Function Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Subcellular Location Secreted.
Post-Translational Modification N- and O-glycosylated.
Tissue Specificity Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Subunit Structure Interacts with DNAJC1.
Sequence Similarities Belongs to the serpin family.


Poduct Presentation

Form Liquid
Preservative 0.02% (w/v) sodium azide
Storage buffer PBS with 50% glycerol, pH 7.3


Storage and Shipping Information

Storage Store at -20 or -80 C. Avoid multiple freeze/thaw cycles.